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Types of Bone Cells | Osteoclasts, Osteoblasts, & Osteocytes

The structure of osteoclasts is related to their function. As osteoclasts have the fate of absorbing bone, they are giant bone cells with specialized membrane structures, ruffled borders and clear zones helping them in function of bone resorption. Osteoclasts originate from liver and spleen as hematopoietic stem cells.


Difference between Osteoblast and Osteoclast ...

(Similarities and Differences between Osteoblast and Osteoclast) Osteoblasts and Osteoclasts are the two types of bone cells which constitute the bone tissue or the osseous tissue. The bone is a metabolically active tissue consisting of several types of cells among which the Osteoblasts and Osteoclasts are the most important ones. Osteoblasts ...


Identification of a novel arthritis-associated osteoclast ...

Osteoclasts have a unique bone-destroying capacity, playing key roles in steady-state bone remodeling and arthritic bone erosion. Whether the osteoclasts in these different tissue settings arise ...


Regulation of NFATc1 in Osteoclast Differentiation

The multinucleated osteoclasts reorganize the actin cytoskeleton to attach to the bone surface and to resorb the bone. Osteoclast differentiation is regulated by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL).


The many ways of osteoclast activation

Osteoclasts are the cells responsible for bone resorption, a process that is essential for the maintenance of healthy bones. Bone diseases, such as osteoporosis, which are characterized by high rates of bone resorption and loss of bone mass, may benefit from treatments that inhibit osteoclast formation and/or function.


Osteoclast Fusion and Fission - PubMed Central (PMC)

Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight into the various steps of the interaction of osteoclast precursors leading to osteoclast formation, surprisingly little is known about what happens with the multinucleated cell itself after it has been formed.


Rapid Screening Method for Osteoclast ... - Clinical Chemistry

Background: Osteoclasts secrete tartrate-resistant acid phosphatase (TRAP; EC [][1]) 5b into the circulation. We studied the release of TRAP 5b from osteoclasts using a mouse in vitro osteoclast differentiation assay. Methods: We developed and characterized a polyclonal antiserum in rabbits, using purified human osteoclastic TRAP 5b as antigen.


Quiz & Worksheet - Osteoblasts & Osteoclasts | Study.com

About This Quiz & Worksheet. Your ability to define osteoblast, osteoclast, cartilage and ossification, among other bone-formation terminology will be assessed in this quiz and worksheet combination.


JCI - Subchondral bone osteoclasts induce sensory ...

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated subchondral bone remodeling in sensory innervation for OA pain. We show that osteoclasts secrete netrin-1 to induce sensory nerve axonal growth in subchondral bone.


Osteoclast Derivation from Mouse Bone Marrow | Protocol

Therefore, we have devised a protocol that allows for the consistent isolation of mouse bone marrow to produce large numbers of multinucleated osteoclasts in vitro, with an approximate yield of 70-80% of cells initially plated forming macrophages and subsequently osteoclasts, in the presence of osteoclast induction media.